Silent inflammation – Why you should know about it

The dual nature of inflammation: Friend or foe

Inflammations are often negatively perceived, even though they can inherently signify something good: they signal that our immune system is active. For example, when our body is attacked by viruses, the immune system responds by triggering inflammation. As soon as this task is completed, the inflammation subsides. But what happens if the inflammation never completely subsides and our body is constantly struggling with a small inflammation? This is known as low-grade chronic inflammation or silent inflammation. And this is exactly what should be prevented!

Why you should know more about silent inflammation

A study by Paul Ridker [1] in 1997 showed that individuals with silent inflammation, who are otherwise considered healthy, have a higher risk of heart attacks than those with low inflammation levels. Ridker measured the CRP (C-reactive protein) levels in over 500 doctors and followed them for 14 years. After 14 years, it was observed that people with high CRP levels (above 2.11mg/L) had a three times higher risk of experiencing a heart attack compared to individuals with low levels (<0.55mg/L).
The CRP-level is a laboratory parameter that provides information about inflammation in the body. In the past, the evaluation was limited to whether the CRP level was high or low to determine the presence of acute inflammation in the body, resulting in a threshold of 10 mg/L. However, more precise measurement methods nowadays allow for a finer differentiation between low and very low CRP levels. According to the American Heart Association, values below 1.0 mg/L are already considered risk factors for cardiovascular diseases [2].

Silent inflammation as a cause of chronic diseases?

It is now known that silent inflammation not only significantly increases the risk of cardiovascular diseases but also for conditions such as obesity, mental stress, fatigue, diabetes, osteoporosis, and many others [3]. Therefore, it is of great importance to keep inflammation in our body as low as possible or, more precisely, to constantly provide our body with the means to combat internal inflammation. As shown in the figure, various environmental and lifestyle factors, particularly poor nutrition, obesity, and stress, have been proven to lead to CRP levels above 1.0 mg/L and consequently, silent inflammation.
© Bildquelle: [3]

How to reduce silent inflammation

An important step in reducing silent inflammation is the reduction of excess body fat. Body fat can further fuel inflammation and thus make controlling inflammation more difficult. Therefore, it is advisable to pay close attention to your diet. In addition to a balanced diet following the mediterranean diet, which is based on vegetables, whole grains, and dairy products, you should also consider the following points:
Olivenöl

Enjoy olive oil daily

Olive oil not only provides valuable fatty acids but also numerous secondary phytonutrients that have anti-inflammatory properties, making it suitable for daily consumption to alleviate inflammation [4].
Kräuter

Cooking more with Herbs

Herbs like basil, thyme, as well as onions and garlic also have anti-inflammatory properties due to their high polyphenol content – a plant chemical. Use fresh herbs in your meals while the summer lasts, and switch to dried versions afterward to reap the health benefits [5].
More exercise

Long-term success through exercise

Although dietary changes can bring quick results, physical activity is required to maintain weight loss in the long term [6]. In addition, physical activity (if not performed at extremely high intensity) has an anti-inflammatory effect. Exercise therefore reduces inflammation in the body.
Schlaf

Reducing inflammation with sleep

Those who sleep poorly or inadequately have higher blood inflammation levels compared to those who get sufficient sleep [7]. During sleep, the body carries out repairs and replaces what is needed, which supports the termination of inflammation processes. Sleep disturbances disrupt these processes and thus contribute to silent inflammation.

Sources

[1] Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997 Apr 3;336(14):973-9. doi: 10.1056/NEJM199704033361401. Erratum in: N Engl J Med 1997 Jul 31;337(5):356. PMID: 9077376.

[2] Sabatine MS, Morrow DA, Jablonski KA, Rice MM, Warnica JW, Domanski MJ, Hsia J, Gersh BJ, Rifai N, Ridker PM, Pfeffer MA, Braunwald E; PEACE Investigators. Prognostic significance of the Centers for Disease Control/American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease. Circulation. 2007 Mar 27;115(12):1528-36. doi: 10.1161/CIRCULATIONAHA.106.649939. Epub 2007 Mar 19. PMID: 17372173.

[3] Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019 Dec;25(12):1822-1832. doi: 10.1038/s41591-019-0675-0. Epub 2019 Dec 5. PMID: 31806905; PMCID: PMC7147972.

[4] Guasch-Ferré M, Li Y, Willett WC, Sun Q, Sampson L, Salas-Salvadó J, Martínez-González MA, Stampfer MJ, Hu FB. Consumption of Olive Oil and Risk of Total and Cause-Specific Mortality Among U.S. Adults. J Am Coll Cardiol. 2022 Jan 18;79(2):101-112. doi: 10.1016/j.jacc.2021.10.041. PMID: 35027106; PMCID: PMC8851878.

[5] Bower A, Marquez S, de Mejia EG. The Health Benefits of Selected Culinary Herbs and Spices Found in the Traditional Mediterranean Diet. Crit Rev Food Sci Nutr. 2016 Dec 9;56(16):2728-46. doi: 10.1080/10408398.2013.805713. PMID: 25749238.

[6] Paixão C, Dias CM, Jorge R, Carraça EV, Yannakoulia M, de Zwaan M, Soini S, Hill JO, Teixeira PJ, Santos I. Successful weight loss maintenance: A systematic review of weight control registries. Obes Rev. 2020 May;21(5):e13003. doi: 10.1111/obr.13003. Epub 2020 Feb 12. PMID: 32048787; PMCID: PMC9105823.

[7] Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011 Aug 5;11(9):607-15. doi: 10.1038/nri3041. PMID: 21818123.

This site uses cookies. By continuing to use the site, you agree to the use of cookies.